Peptide Database

Peptide NameNatriuretic peptide

Function Ontology

Cardiovascular

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Hormonal / Endocrine ▸ Hormone peptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length53 amino acids

Chemical FormulaC256H413N81O76S2

DescriptionStandard

        EVKYDPCFGHKIDRINHVSNLGCPSLRDPRPTAPAALRIIRDLHPDSKQSQAA
    

Molecular Weight5905.65 Da

Isoelectric Point (pI)8.84

Net Charge (pH 7.0)2.08

Net Charge (pH 7.4) 1.72

Charge Density (pH 7.0) 0.0392

GRAVY Index-0.68

Hydrophobic Moment 0.73

Boman Index-0.17

Instability Index55.82

Aliphatic Index 79.25

Aromaticity 0.0377

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2514.92

LogP -27.79

H-bond Donors 87.0

H-bond Acceptors 83.0

Rotatable Bonds 189.0

Heavy Atoms 415.0

Ring Count 11.0

Amide Bonds 56.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0338435 VERIFIED: NO

Provenance & Taxonomy

OrganismDendroaspis angusticeps [Animal]

FamilyNatriuretic peptide

Tax ID8618

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide7-23

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Metabolic regulation Physiological regulation Receptor modulation

Half-LifeMammalian: 1 hour; Yeast: 30 min; E. coli: >10 hour