Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length507 amino acids

Chemical FormulaC2572H3988N640O744S15

DescriptionStandard

        MHTKTVGVLWGCFFLWNLYTSSAQTIYPGIKARATQRALDYGVQAGMEMIEQMLKEKNIPDLKGSESLEFLKVDYVNYNFSNIKINAFSFPNTSLAFVPGVGIKALTNHGTANISTDWEIKSPLFQDTGGADLFLSGVYFTGIIVLARNDFGHPILKLQDCYAQVNHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIIMNEVEALNANLSTIEVLTKIDNYTLLDYSLISSPEITENYIDLNLKGIVYPLEDLTDPPFSPVPFVLPERSDSMLYVGISEFFFKSASFAYFTAGAFNVTLSTKEISNHLVQNSQGVGNVLSRIAEIYILSQPFLVRVMATEPPVISLLPGNFTLDIPASIMILTQSKNSTAEAIVSMDFVASTSVGLVILGQRLVCSLSLNRFRLSLPESNRSNIEVLRFENILSSILHFGILPLANAKLQQGFPLPNPHKISFVNSDIEVFEGFLLISTDLKYETSLKQQPSFHGWEGLNFINGQWRGKPAA
    

Molecular Weight56259.99 Da

Isoelectric Point (pI)5.22

Net Charge (pH 7.0)-12.69

Net Charge (pH 7.4) -13.54

Charge Density (pH 7.0) -0.0250

GRAVY Index0.15

Hydrophobic Moment 0.67

Boman Index0.18

Instability Index37.86

Aliphatic Index 102.49

Aromaticity 0.1065

Extinction Coeff. Reduced 51340.00

Extinction Coeff. Oxidized 51590.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0065647 VERIFIED: NO

Provenance & Taxonomy

OrganismPanthera tigris altaica [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence