Peptide Database

Peptide NameEKL1C

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length40 amino acids

Chemical FormulaC211H328N46O70S2

DescriptionStandard

        NVTFLDLEYEMKKLEEAIKKLEESYIDLKELGTYEYGSGC
    

Molecular Weight4693.26 Da

Isoelectric Point (pI)4.39

Net Charge (pH 7.0)-5.23

Net Charge (pH 7.4) -5.48

Charge Density (pH 7.0) -0.1309

GRAVY Index-0.56

Hydrophobic Moment 0.75

Boman Index-0.03

Instability Index15.32

Aliphatic Index 87.75

Aromaticity 0.1250

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 5960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1906.25

LogP -12.90

H-bond Donors 66.0

H-bond Acceptors 67.0

Rotatable Bonds 164.0

Heavy Atoms 329.0

Ring Count 5.0

Amide Bonds 40.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0425325 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHR2 fusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermChol

Other ModsChol

Bio-Activity Profile

Function

Antiviral Fusion inhibition

Targetwide type

Activity0.049±0.007 μM

MethodIC50

Half-LifeMammalian: 1.4 h; Yeast: 3 min; E. coli: >10 h

PaperA highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases. | Zhou J, Xu W, Liu Z, Wang C, Xia S, Lan Q, Cai Y, Su S, Pu J, Xing L, Xie Y, Lu L, Jiang S, Wang Q. | Acta Pharm Sin B. 2021 Aug 2. | DOI:10.1016/j.apsb.2021.07.026 | PMID:34367893 PMID34367893 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34367893/

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