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MYP_113871
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Basic Information
EKL1C
Anticancer
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
40 amino acids
C211H328N46O70S2
Standard
Sequence
NVTFLDLEYEMKKLEEAIKKLEESYIDLKELGTYEYGSGC
Physicochemical Analysis
4693.26 Da
4.39
-5.23
-5.48
-0.1309
-0.56
0.75
-0.03
15.32
87.75
0.1250
5960.00
5960.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1906.25
-12.90
66.0
67.0
164.0
329.0
5.0
40.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0007507 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical conjugated peptide [Modified]
None
Chol
C-terminal cholesterol conjugation
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2 Antiviral Anti-coronavirus Fusion inhibition
SARS-CoV-2 Omicron; Calu-3 cells
0.01218 μM
IC50 (cell-cell fusion inhibition)
PaperA highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases. Acta Pharm Sin B. 2022 Apr;12(4):1652-1661. doi: 10.1016/j.apsb.2021.07.026. PMID: 34367893 PMID35087243;34367893 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35087243/
RECORD: Rec_0013089 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
Chol
Chol
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Fusion inhibition Anti-coronavirus
SARS-CoV-2 D614G pseudovirus
0.0236 μM
IC50 (pseudovirus infection inhibition)
Mammalian: 1.4 h; Yeast: 3 min; E. coli: >10 h
PaperPeptide-based pan-CoV fusion inhibitors maintain high potency against SARS-CoV-2 Omicron variant. | Xia S, Chan JF, Wang L, Jiao F, Chik KK, Chu H, Lan Q, Xu W, Wang Q, Wang C, Yuen KY, Lu L, Jiang S. | Cell Res. 2022 Apr;32(4):404-406. | DOI:10.1038/s41422-022-00617-x | PMID:35087243 PMID35087243 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35087243/
RECORD: Rec_0014262 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
Chol
Chol
Bio-Activity Profile
Antiviral Fusion inhibition Anti-coronavirus
SARS-CoV-2 K417N/E484K/N501Y pseudovirus
0.12±0.009 μM
IC50 (pseudovirus infection inhibition)
Mammalian: 1.4 h; Yeast: 3 min; E. coli: >10 h
PaperA highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases. | Zhou J, Xu W, Liu Z, Wang C, Xia S, Lan Q, Cai Y, Su S, Pu J, Xing L, Xie Y, Lu L, Jiang S, Wang Q. | Acta Pharm Sin B. 2021 Aug 2. | DOI:10.1016/j.apsb.2021.07.026 | PMID:34367893 PMID34367893 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34367893/
RECORD: Rec_0018629 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical conjugated peptide [Modified]
None
Chol
C-terminal cholesterol conjugation
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2 Antiviral Anti-coronavirus Fusion inhibition
SARS-CoV-2 N501Y pseudovirus
0.069±0.006 μM
IC50 (pseudovirus infection inhibition)
PaperA highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases. Acta Pharm Sin B. 2022 Apr;12(4):1652-1661. doi: 10.1016/j.apsb.2021.07.026. PMID: 34367893 PMID35087243;34367893 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35087243/
RECORD: Rec_0021691 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
Chol
Chol
Bio-Activity Profile
Antiviral Anti-CoV-WIV1 Fusion inhibition Anti-coronavirus
SARS-related coronavirus WIV1 pseudovirus
0.218±0.013 μM
IC50
Mammalian: 1.4 h; Yeast: 3 min; E. coli: >10 h
PaperA highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases. | Zhou J, Xu W, Liu Z, Wang C, Xia S, Lan Q, Cai Y, Su S, Pu J, Xing L, Xie Y, Lu L, Jiang S, Wang Q. | Acta Pharm Sin B. 2021 Aug 2. | DOI:10.1016/j.apsb.2021.07.026 | PMID:34367893 PMID34367893 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34367893/
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