Peptide Database

Peptide NameHNH endonuclease domain protein

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Enzyme / Catalytic activity ▸ Hydrolase

Enzyme / Catalytic activity ▸ Hydrolase ▸ Nuclease

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length396 amino acids

Chemical FormulaC1978H2982N532O589S7

DescriptionStandard

        MKGCTDAGTAEEPAENFGQVAIFAQPVVDDCCGYHHPEANVIGEPAEAQTMLLFPSSVLATQIWGKWSLSGVLSATRGSYIGALASALYIPSAGEGSARVPGRDEFWYEEELRQKALAGSTATTRVRFFWGTDIHGKPQVYGVHTGEGTPYENVRVANMQWNEQTQRYEFTPAHDVDGPLITWTPENPEHGNVPGHTGNDRPPLDQPTILVTPIPDGTDTYTTPPFPVPDPKEFNDYILVFPAGSGIKPIYVYLKEDPRKLPGVVTGRGVPLSPGTRWLDMSVSNNGNGAPIPAHIADKLRGREFKTFDEFREALWLEVSKDSVLLAQFIKSNQNNVSQGYSPYVPEEGYYYGPNEIVKKFQIHHVVAIEHGGGVYDIDNFRIVTPRLHDEIHYRR
    

Molecular Weight43862.50 Da

Isoelectric Point (pI)5.25

Net Charge (pH 7.0)-15.33

Net Charge (pH 7.4) -16.35

Charge Density (pH 7.0) -0.0387

GRAVY Index-0.45

Hydrophobic Moment 0.52

Boman Index0.04

Instability Index30.22

Aliphatic Index 72.85

Aromaticity 0.1061

Extinction Coeff. Reduced 70820.00

Extinction Coeff. Oxidized 70945.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0386240 VERIFIED: YES

Provenance & Taxonomy

OrganismEscherichia coli 908519 [Bacterium]

FamilyPyocin/Colicin

Tax ID1268991

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Anti-Gram-negative Endonuclease Hydrolase Nuclease Non-hemolytic Non-ribosomal

TargetEscherichia coli