Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length469 amino acids

Chemical FormulaC2335H3692N592O653S10

DescriptionStandard

        MLWLLVVLLGVGTEAVTPGIKTKITLKGLDYGKQVGMEFLKLALLQLPIPDFRGSYSVPLVGQVEYAVTGFQVNTINLGESLVAFAPSSRIKLSMGSAEAQVNGHWSVKVSLIHDNGTLKLHVGDMMLAVLIEVGWDGTGRLVVSPAGCSCHIGHLDVTFYGGASWLYNIFTGALEHVLRQELGNKLCKEIQNAVEALEQTLQTIPESSHISSLADLDYSLVAPPLITEQSIELNLKGEFYSRAGHKEAPVPPAPFSFWEQNDRMLLLGVSDFVANSAAFVYYGAGALSWNLTDSTVPKKFPIHINTKIFKGLVPELLKRFPDTPMALQIFARLPPWLQTQPGTLQLLLPGAVQAFILPNGTSPVPVFLLHVDIEASAQVFISGKNIGASLKLTNVSLTLAHSDVGPFPVDRIETLLYVALKAAILPRINRKLKEGLPLPTLPKTSLQDTAINIQEGFLVIATNVQYGA
    

Molecular Weight50826.52 Da

Isoelectric Point (pI)6.27

Net Charge (pH 7.0)-3.52

Net Charge (pH 7.4) -4.44

Charge Density (pH 7.0) -0.0075

GRAVY Index0.27

Hydrophobic Moment 0.78

Boman Index0.22

Instability Index40.83

Aliphatic Index 112.45

Aromaticity 0.0810

Extinction Coeff. Reduced 54890.00

Extinction Coeff. Oxidized 55015.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0257343 VERIFIED: NO

Provenance & Taxonomy

OrganismVombatus ursinus [Bacterium]

FamilyBPI

Tax ID29139

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence