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MYP_113817
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Basic Information
Alloferon-1 [H1A]
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
13 amino acids
C49H74N20O16
Standard
Sequence
AGVSGHGQHGVHG
Physicochemical Analysis
1199.24 Da
7.06
0.06
-0.28
0.0044
-0.44
0.26
0.23
-14.70
52.31
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
561.88
-9.14
19.0
19.0
37.0
85.0
3.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0012597 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Non-cytotoxic
Vero cells
Cell viability/cytotoxicity assay (no toxicity up to 187 μg/mL)
PaperKuczer M et al. Further studies on the antiviral activity of alloferon and its analogues. J Pept Sci. 2011. DOI:10.1002/psc.1388. PMID:21766388. PMID21766388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21766388/
RECORD: Rec_0027675 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Coxsackievirus B2 strain 971 PT; LLC-MK2 cells
358 μg/mL
IC50 (virus replication inhibition)
PaperKuczer M et al. Further studies on the antiviral activity of alloferon and its analogues. J Pept Sci. 2011. DOI:10.1002/psc.1388. PMID:21766388. PMID21766388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21766388/
RECORD: Rec_0033603 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
herpes simplex virus type 1 (HSV-1)
Virus replication inhibition assay (qualitative result)
PaperKuczer M et al. Further studies on the antiviral activity of alloferon and its analogues. J Pept Sci. 2011. DOI:10.1002/psc.1388. PMID:21766388. PMID21766388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21766388/
RECORD: Rec_0073668 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Non-cytotoxic
HEp-2 cells
Cell viability/cytotoxicity assay (no toxicity up to 187 μg/mL)
PaperKuczer M et al. Further studies on the antiviral activity of alloferon and its analogues. J Pept Sci. 2011. DOI:10.1002/psc.1388. PMID:21766388. PMID21766388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21766388/
RECORD: Rec_0077892 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Alloferon
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Replication inhibition
Coxsackievirus B2 strain 971 PT; LLC-MK2 cells
358 μg/mL
IC50 (virus replication inhibition)
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperFurther studies on the antiviral activity of alloferon and its analogues. | Kuczer M, Midak-Siewirska A, Zahorska R, Luczak M, Konopińska D. | J Pept Sci. 2011 Nov;17(11):715-9. | DOI:10.1002/psc.1388 | PMID:21766388 PMID21766388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21766388/
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