Peptide Database

Peptide NameSLAY-screened peptide P4813

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC105H151N23O26S

DescriptionStandard

        SGVPVFSPFGVYHLIVQYAC
    

Molecular Weight2183.53 Da

Isoelectric Point (pI)6.45

Net Charge (pH 7.0)-0.46

Net Charge (pH 7.4) -0.74

Charge Density (pH 7.0) -0.0232

GRAVY Index1.00

Hydrophobic Moment 0.29

Boman Index0.51

Instability Index88.56

Aliphatic Index 102.00

Aromaticity 0.2000

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 751.33

LogP -3.85

H-bond Donors 26.0

H-bond Acceptors 28.0

Rotatable Bonds 61.0

Heavy Atoms 155.0

Ring Count 7.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0057615 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/