Peptide Database

Peptide NamePotassium channel toxin alpha-KTx 9.11

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length27 amino acids

Chemical FormulaC117H185N33O41S7

DescriptionStandard

        VGCEECPMHCKGKKALPTCDYGCECND
    

Molecular Weight2934.37 Da

Isoelectric Point (pI)5.01

Net Charge (pH 7.0)-2.23

Net Charge (pH 7.4) -2.59

Charge Density (pH 7.0) -0.0825

GRAVY Index-0.58

Hydrophobic Moment 0.35

Boman Index-0.10

Instability Index81.50

Aliphatic Index 28.89

Aromaticity 0.0370

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1179.13

LogP -13.94

H-bond Donors 44.0

H-bond Acceptors 47.0

Rotatable Bonds 95.0

Heavy Atoms 198.0

Ring Count 4.0

Amide Bonds 27.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0243258 VERIFIED: NO

Provenance & Taxonomy

OrganismMesobuthus gibbosus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Toxin

TargetKv1.2/KCNA2, Kv1.3/KCNA3, Kv1.6/KCNA6

RECORD: Rec_0305830 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Toxic Cytotoxic