Peptide Database

Peptide NameMetreleptin

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Standard StatusStandard

Sequence Length147 amino acids

Chemical FormulaC714H1169N191O221S6

DescriptionStandard

        MVPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQKVTGLDFIPGLHPILTLSKMDQTLAVYQQILTSMPSRNVIQISNDLENLRDLLHVLAFSKSCHLPWASGLETLDSLGGVLEASGYSTEVVALSRLQGSLQDMLWQLDLSPGC
    

Molecular Weight16157.46 Da

Isoelectric Point (pI)5.70

Net Charge (pH 7.0)-3.16

Net Charge (pH 7.4) -3.63

Charge Density (pH 7.0) -0.0215

GRAVY Index0.05

Hydrophobic Moment 0.66

Boman Index0.10

Instability Index43.92

Aliphatic Index 112.65

Aromaticity 0.0408

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6610.67

LogP -67.69

H-bond Donors 228.0

H-bond Acceptors 228.0

Rotatable Bonds 543.0

Heavy Atoms 1132.0

Ring Count 18.0

Amide Bonds 161.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0332967 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Escherichia coli [Bacterium]

FamilyInsulin

Tax ID9606;562

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsLipidation

Bio-Activity Profile

Function

Hormone replacement

Half-Life3.8 to 4.7 hours

RECORD: Rec_0418190 VERIFIED: YES