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MYP_113438
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Basic Information
Alloferon-1 (Insects, animals)
Anticancer
Anticancer ▸ Antitumor
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Enzyme modulation ▸ Enzyme inhibition ▸ Reactivation inhibitor
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Standard
13 amino acids
C52H76N22O16
Standard
Sequence
HGVSGHGQHGVHG
Physicochemical Analysis
1265.30 Da
7.10
0.11
-0.30
0.0084
-0.82
0.26
0.15
-22.68
44.62
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
590.56
-9.19
20.0
20.0
39.0
90.0
4.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0271884 VERIFIED: YES
Provenance & Taxonomy
Calliphora vicina [Animal]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Anticancer
Human influenza virus A/Aichi/2/68 (H3N2); mouse infection model
25 μg per mouse
In vivo antiviral efficacy assay
PMID12235362 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12235362/
RECORD: Rec_0276602 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Blow fly [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
allo-residue reported
Bio-Activity Profile
Antimicrobial Antiviral Anticancer
Staphylococcus epidermidis penicillin-resistant
32 μg/mL
MIC
PaperNovel antiviral and antitumoral peptides from insects. PMID12235362
RECORD: Rec_0322567 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Blow fly [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
allo-residue reported
Bio-Activity Profile
Antimicrobial Antiviral Anticancer
Pseudomonas aeruginosa ATCC 27853 or penicillin-resistant
8-32 μg/mL
MIC
PaperNovel antiviral and antitumoral peptides from insects. PMID12235362
RECORD: Rec_0334780 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Blow fly [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
allo-residue reported
Bio-Activity Profile
Antimicrobial Antiviral Anticancer
Klebsiella pneumoniae ATCC 13883 or penicillin-resistant
16 μg/mL
MIC
PaperNovel antiviral and antitumoral peptides from insects. PMID12235362
RECORD: Rec_0345707 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Antibacterial
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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