Peptide Database

Peptide NameSLAY-screened peptide P680

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC115H167N33O29S

DescriptionStandard

        CVLEINVNHYWHHREALFNI
    

Molecular Weight2507.82 Da

Isoelectric Point (pI)6.26

Net Charge (pH 7.0)-0.98

Net Charge (pH 7.4) -1.36

Charge Density (pH 7.0) -0.0492

GRAVY Index-0.09

Hydrophobic Moment 0.20

Boman Index0.13

Instability Index65.95

Aliphatic Index 112.00

Aromaticity 0.1500

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1004.05

LogP -5.51

H-bond Donors 35.0

H-bond Acceptors 32.0

Rotatable Bonds 78.0

Heavy Atoms 178.0

Ring Count 7.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0296082 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/