Peptide Database

Peptide NameProkineticin-1

Function Ontology

Cardiovascular

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length86 amino acids

Chemical FormulaC414H660N130O114S12

DescriptionStandard

        AVITGACERDVQCGAGTCCAISLWLRGLRMCTPLGREGEECHPGSHKVPFFRKRKHHTCPCLPNLLCSRFPDGRYRCSMDLKNINF
    

Molecular Weight9667.25 Da

Isoelectric Point (pI)8.94

Net Charge (pH 7.0)6.06

Net Charge (pH 7.4) 5.50

Charge Density (pH 7.0) 0.0704

GRAVY Index-0.29

Hydrophobic Moment 0.75

Boman Index-0.08

Instability Index51.25

Aliphatic Index 64.65

Aromaticity 0.0698

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3891.30

LogP -41.29

H-bond Donors 147.0

H-bond Acceptors 136.0

Rotatable Bonds 313.0

Heavy Atoms 670.0

Ring Count 17.0

Amide Bonds 89.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0039214 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyProkineticin

Tax ID9606

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide7-19; 13-31; 18-59; 41-67; 61-77

Bio-Activity Profile

Function

Cardiovascular Growth regulation Development regulation ACE inhibitory

Targetcontracts gastrointestinal (GI) smooth muscle

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0042183 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyProkineticin

Tax ID9606

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide7-19; 13-31; 18-59; 41-67; 61-77

Bio-Activity Profile

Function

Cardiovascular Growth regulation Development regulation ACE inhibitory

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0225125 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyProkineticin

Tax ID9606

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide7-19; 13-31; 18-59; 41-67; 61-77

Bio-Activity Profile

Function

Cardiovascular Growth regulation Development regulation ACE inhibitory

Targetcapillary endothelial cells derived from endocrine gland

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour