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MYP_113264
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Basic Information
15
Anticancer
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
3 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
YXG
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0119515 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
X=Cα -dialkylated glycine (Aaa2,S )
Bio-Activity Profile
Antimicrobial Anticancer
HBL
3.3; 19.4 %
% growth inhibition at 100/1000 μM
PaperTumor-cell-targeted methionine-enkephalin analogues containing unnatural amino acids: design, synthesis, and in vitro antitumor activity. J Med Chem. 2006 Jun 1;49(11):3136-42. doi: 10.1021/jm051026+. PMID: 16722632. PMID16722632 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16722632/
RECORD: Rec_0128686 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
X=Cα -dialkylated glycine (Aaa2,R )
Bio-Activity Profile
Antimicrobial Anticancer
CaCo-2
6.9; 8.1; 8.6 %
% growth inhibition at 10/100/1000 μM
PaperTumor-cell-targeted methionine-enkephalin analogues containing unnatural amino acids: design, synthesis, and in vitro antitumor activity. J Med Chem. 2006 Jun 1;49(11):3136-42. doi: 10.1021/jm051026+. PMID: 16722632. PMID16722632 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16722632/
RECORD: Rec_0146602 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
X=Cα -dialkylated glycine (Aaa2,S )
Bio-Activity Profile
Antimicrobial Anticancer
MCF-7
15.6 %
Inhibition
PaperTumor-cell-targeted methionine-enkephalin analogues containing unnatural amino acids: design, synthesis, and in vitro antitumor activity. J Med Chem. 2006 Jun 1;49(11):3136-42. doi: 10.1021/jm051026+. PMID: 16722632. PMID16722632 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16722632/
RECORD: Rec_0188212 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
X=Cα -dialkylated glycine (Aaa2,S )
Bio-Activity Profile
Antimicrobial Anticancer
HeLa
11.7; 11.6; 28.2 %
% growth inhibition at 10/100/1000 μM
PaperTumor-cell-targeted methionine-enkephalin analogues containing unnatural amino acids: design, synthesis, and in vitro antitumor activity. J Med Chem. 2006 Jun 1;49(11):3136-42. doi: 10.1021/jm051026+. PMID: 16722632. PMID16722632 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16722632/
RECORD: Rec_0190613 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
X=Cα -dialkylated glycine (Aaa2,S )
Bio-Activity Profile
Antimicrobial Anticancer
MCF-7
21.2 %
Inhibition
PaperTumor-cell-targeted methionine-enkephalin analogues containing unnatural amino acids: design, synthesis, and in vitro antitumor activity. J Med Chem. 2006 Jun 1;49(11):3136-42. doi: 10.1021/jm051026+. PMID: 16722632. PMID16722632 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16722632/
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