Peptide Database

Peptide NameE1P37

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC87H137N21O28S2

DescriptionStandard

        PVPNLTCAVACELKWESE
    

Molecular Weight1989.27 Da

Isoelectric Point (pI)4.52

Net Charge (pH 7.0)-2.05

Net Charge (pH 7.4) -2.14

Charge Density (pH 7.0) -0.1138

GRAVY Index0.06

Hydrophobic Moment 0.30

Boman Index0.13

Instability Index71.94

Aliphatic Index 86.67

Aromaticity 0.0556

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5625.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 772.50

LogP -6.43

H-bond Donors 28.0

H-bond Acceptors 28.0

Rotatable Bonds 61.0

Heavy Atoms 138.0

Ring Count 4.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0032601 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAurein

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetHIV-1 NL4-3

Activity41±8.7 μM

MethodIC50

RECORD: Rec_0157347 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetVirus:HIV-1 NL4-3:inhibition of virus infection in TZM-bl cells

Activity41±8.7 μM

MethodIC50

RECORD: Rec_0407176 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1 NL4-3 | TZM-bl cells

Activity41±8.7 μM

MethodIC50

Half-LifeMammalian: >20 h; Yeast: >20 h; E. coli: ?

PaperDefinition of an 18-mer Synthetic Peptide Derived from the GB virus C E1 Protein as a New HIV-1 Entry Inhibitor. | Gómara MJ, Sánchez-Merino V, Paús A, Merino-Mansilla A, Gatell JM, Yuste E, Haro I. | Biochim Biophys Acta. 2016 Jun;1860(6):1139-48. | DOI:10.1016/j.bbagen.2016.02.008 | PMID:26905802 PMID26905802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26905802/