Peptide Database

Peptide NameAcidic phospholipase A2 BthA-1 (svPLA2) (EC 3.1.1.4) (BOJU-III) (BthA-I-PLA2) (Hypotensive phospholipase A2) (Phosphatidylcholine 2-acylhydrolase)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Enzyme / Catalytic activity ▸ Hydrolase

Enzyme modulation ▸ Enzyme inhibition ▸ Blood coagulation cascade inhibitor

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length138 amino acids

Chemical FormulaC672H1022N176O207S18

DescriptionStandard

        MRTLWIMAVLLVGVEGSLWQFGKMINYVMGESGVLQYLSYGCYCGLGGQGQPTDATDRCCFVHDCCYGKVTGCDPKIDSYTYSKKNGDVVCGGDDPCKKQICECDRVATTCFRDNKDTYDIKYWFYGAKNCQEKSEPC
    

Molecular Weight15455.53 Da

Isoelectric Point (pI)5.33

Net Charge (pH 7.0)-2.54

Net Charge (pH 7.4) -3.06

Charge Density (pH 7.0) -0.0184

GRAVY Index-0.33

Hydrophobic Moment 0.65

Boman Index0.01

Instability Index26.57

Aliphatic Index 57.83

Aromaticity 0.1232

Extinction Coeff. Reduced 31400.00

Extinction Coeff. Oxidized 32275.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6175.25

LogP -62.66

H-bond Donors 227.0

H-bond Acceptors 224.0

Rotatable Bonds 506.0

Heavy Atoms 1073.0

Ring Count 25.0

Amide Bonds 147.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0190887 VERIFIED: YES

Provenance & Taxonomy

OrganismBothrops jararacussu [Animal]

FamilyPhospholipase A2; Group II subfamily; D49 sub-subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Anti-Gram-negative Hydrolase Blood coagulation cascade inhibitor Antiplatelet Toxin Hypotensive Non-hemolytic

TargetEscherichia coli (Gram-negative)