Peptide Database

Peptide NameNprE signal peptide

Function Ontology

Annotation / Sequence feature ▸ Signal peptide

Biotechnology / Production and expression ▸ Secretory expression optimization

Enzyme / Catalytic activity ▸ Hydrolase ▸ Protease/Peptidase

Standard StatusStandard

Sequence Length27 amino acids

Chemical FormulaC122H211N33O34S

DescriptionStandard

        VGLGKKLSVRVAASFMSLSISLPGVQA
    

Molecular Weight2716.25 Da

Isoelectric Point (pI)11.17

Net Charge (pH 7.0)2.73

Net Charge (pH 7.4) 2.52

Charge Density (pH 7.0) 0.1012

GRAVY Index0.89

Hydrophobic Moment 0.47

Boman Index0.29

Instability Index23.60

Aliphatic Index 126.30

Aromaticity 0.0370

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1069.31

LogP -10.94

H-bond Donors 38.0

H-bond Acceptors 38.0

Rotatable Bonds 91.0

Heavy Atoms 190.0

Ring Count 2.0

Amide Bonds 27.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0329629 VERIFIED: YES

Provenance & Taxonomy

OrganismBacillus subtilis [Bacterium]

FamilySec signal peptide

Tax ID1423

Structure & Mods

Configlinear signal peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Protein secretion signal peptide Secretory expression optimization Aminopeptidase (AP) secretion

TargetBacillus subtilis WB600

Activity4.82 U/mL

MethodAminopeptidase activity assay

PaperGuan C, Cui W, Cheng J, et al. Construction of a highly active secretory expression system via an engineered dual promoter and a highly efficient signal peptide in Bacillus subtilis[J]. New Biotechnology, 2016, 33(3): 372-379. PMID26820123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26820123/