Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length440 amino acids

Chemical FormulaC2218H3508N600O616S10

DescriptionStandard

        AHQQAITILEKELAQLKLKDISGDSRIRHVGKVHYEISRLSLRSFHLPHSRISLVPGVGLQVSISNAFAEVDGNWRVKLLFIRDHGSFHLKVENVYIKVNLKLSSDGSGKPTISSSNCNTRISRVRVRFSGRLGWLYNLFHSTIESRFRKLLESKVCEVVASSVRKNLQPYLQTLPVTARIDATAGIDYSLVAPPTATAQSLDVDLKGEFFSLAHHSAVPFSPPPLALPPDHDRMVYFGVSSYFFNTAGFTYQAAGALVFEITDSLIPKGFDFHLNTTTFSAFIPQLDKMYPDMPMKLRLSAPSAPFLSIGPKGLSLRPVVDIQAYAILPNSSLVPLFLLSLVSNVSAVVDVKSGHVAGSLGACRMKLSLKHSDVGTFQVRMLQSIMNIFSSSILLPNLNERLNQGFPLPLPDRIQLSNILVRFYQNFLLLGADVQYQPR
    

Molecular Weight48755.88 Da

Isoelectric Point (pI)9.68

Net Charge (pH 7.0)15.01

Net Charge (pH 7.4) 13.99

Charge Density (pH 7.0) 0.0341

GRAVY Index0.09

Hydrophobic Moment 0.72

Boman Index0.10

Instability Index38.30

Aliphatic Index 103.66

Aromaticity 0.0909

Extinction Coeff. Reduced 28880.00

Extinction Coeff. Oxidized 29005.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0032346 VERIFIED: NO

Provenance & Taxonomy

OrganismColius striatus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria