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MYP_113017
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Basic Information
Covid3
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
29 amino acids
C156H244N40O44S
Standard
Sequence
LQTALYALMEEIHIAALEKTWTALRHQYT
Physicochemical Analysis
3415.91 Da
6.02
-1.06
-1.37
-0.0366
0.01
0.48
0.14
63.74
111.38
0.1034
8480.00
8480.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1358.65
-8.26
48.0
46.0
111.0
241.0
6.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0253496 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Acylation
Amidation
Acylation
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Infection inhibition
SARS-CoV-2 | Vero cells
6.56±2.14 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperComputational Design of Potent D-Peptide Inhibitors of SARS-CoV-2. | Valiente PA, Wen H, Nim S, Lee J, Kim HJ, Kim J, Perez-Riba A, Paudel YP, Hwang I, Kim KD, Kim S, Kim PM. | J Med Chem. 2021 Oct 28;64(20):14955-14967. | DOI:10.1021/acs.jmedchem.1c00655 | PMID:34624194 PMID34624194 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34624194/
RECORD: Rec_0328745 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Acylation
Amidation
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
Virus
PMID34624194 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34624194/
RECORD: Rec_0328952 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Acylation
Amidation
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
SARS-CoV-2:inhibition of infection in Vero cells
6.56±2.14 μM
IC50
PMID34624194 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34624194/
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