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MYP_113002
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Basic Information
Panitide L2
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
28 amino acids
C130H209N37O38S6
Standard
Sequence
QLPICGETCVLGGCYTPNCRCQYPICVR
Physicochemical Analysis
3090.67 Da
7.77
0.70
0.41
0.0251
0.25
0.25
0.10
7.81
76.43
0.0714
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1193.94
-12.57
46.0
45.0
93.0
211.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0024004 VERIFIED: YES
Provenance & Taxonomy
Panicum laxum [Plant]
Cyclotide
Structure & Mods
Backbone-cyclized cyclotide scaffold with cystine-knot family annotation [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID23195955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23195955/
RECORD: Rec_0129916 VERIFIED: YES
Provenance & Taxonomy
Insecta [Animal]
50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID23093034 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23093034/
RECORD: Rec_0139580 VERIFIED: YES
Provenance & Taxonomy
Panicum laxum [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Pyroglutamylation
N-terminus is a pyroglutamate (XXQ)
Bio-Activity Profile
Antimicrobial Anticancer
50% hemolysis at 15 uM
15 μM
HC50
PaperDiscovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants.
RECORD: Rec_0148889 VERIFIED: YES
Provenance & Taxonomy
Panicum laxum [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Pyroglutamate
None
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Cytotoxic Anticancer
HeLa cells
PMID23195955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23195955/
RECORD: Rec_0157568 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
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