Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length487 amino acids

Chemical FormulaC2436H3872N644O684S21

DescriptionStandard

        TREDMARGPCNAPRWASLLVLVVMSTAVAAAINPGVVVRISQKGLDYAAQQGTAVLQKELERIKIPDYSGSFKIKHLGKGHYSFYSMDIREFQLPSSQIRMVPNVGLKFSISNANIKISGQWKARKSFLKTSGRFDLSIEGMSISADLKLGSNLTSGKPTVTCSSCSSHISSVHVHISNSKVGWLIRLFHKKIESALQNKLNSQVCQEVTSSVSSKLQPYLQTLPVMTKIDAVAGINYGLVAPPTTTAETLDVQMKGEFYRLNHHNPPPFAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLTDDMIPKESKFRLTTKFFGSFLPEVAKMFPNMKIQIHISASAPPQLSIQPTGLSFFPALDIQAFAVLANSSLASLFLIGMSTHGSLEVGVRSDRLVGELKVDRLLLELKHSNIGPFPVELLQDIMNYIIPTLVLPRVNEKLQKGFPLPMPARVQLYNMVLQSHQNFLLFGADVIYK
    

Molecular Weight53798.07 Da

Isoelectric Point (pI)9.47

Net Charge (pH 7.0)14.52

Net Charge (pH 7.4) 13.50

Charge Density (pH 7.0) 0.0298

GRAVY Index0.04

Hydrophobic Moment 0.67

Boman Index0.11

Instability Index42.74

Aliphatic Index 96.88

Aromaticity 0.0842

Extinction Coeff. Reduced 35870.00

Extinction Coeff. Oxidized 36120.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0393563 VERIFIED: NO

Provenance & Taxonomy

OrganismCallithrix jacchus [Animal]

FamilyBPI/LBP

Tax ID9483

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence