‹ ›
MYP_112815
← PREVIOUS NEXT → BACK
Basic Information
A (I17K) (Derived from AR-23)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
23 amino acids
C111H191N31O28
Standard
Sequence
AIGSILGALAKGLPTLKSWIKNR
Physicochemical Analysis
2407.89 Da
11.26
3.79
3.60
0.1649
0.37
0.55
0.19
11.55
131.74
0.0435
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
954.26
-7.54
34.0
32.0
81.0
170.0
3.0
23.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0212341 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human red blood cells
10 % hemolysis at 50 μM
Hemolysis
PMID27271216 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27271216/
RECORD: Rec_0223189 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Cytotoxic
PaperDesign of an α-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm activity. Sci Rep. 2016 Jun 8;6:27394. doi: 10.1038/srep27394. PMID: 27271216. PMID27271216 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27271216/
RECORD: Rec_0224869 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa CGMCC 1.2421
25 μM
MIC
PMID27271216 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27271216/
RECORD: Rec_0245831 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
human red blood cells
PaperDesign of an α-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm activity. Sci Rep. 2016 Jun 8;6:27394. doi: 10.1038/srep27394. PMID: 27271216. PMID27271216 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27271216/
RECORD: Rec_0258023 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Cytotoxic
In L929 cells, the cell viability is 98%, 92%, 53%, 34% and 7
PaperDesign of an α-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm activity. Sci Rep. 2016 Jun 8;6:27394. doi: 10.1038/srep27394. PMID: 27271216. PMID27271216 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27271216/
FIRST PREV 1 2 3 4 NEXT LAST
Showing 5 records on this page · Page 2 of 4