Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length459 amino acids

Chemical FormulaC2319H3654N586O670S18

DescriptionStandard

        MKACCSLLLLGLVCVQLKANPGVKVRLTQKGLEYAKEVGLEILKQNMEKERFPDLTGYEKFGLGNVKYNISRIRIATVEFPSASMSLIPRTGIKLVIGNASLTADMNWNIRTWMFRDSGRSTVYISKVFVTAIFSTPLDNSGHTLISLTSCRTTSGDIDIKLNGKSGFLHNFFIKYLKKPIHRSLATNSCPNIRSGIQLISEDLQSLNVLMPIDDLAEIDYSLNSLPAVFRPYIELDLKGIVHPAGNYTGPPYVAAPFTIPDQTDSMLYLAFSEYFFQTSSFAYYTAGAFNRTIAEETYSYFNISTEIFGSIIPEVAKYSVTPYPVMLKLMATETPLISLQPDSFTLEIQGSMEVFAVLPDSTNQSLFTMNTTANTSIALNIFNQKLMGSLCLNRLQFSLTHSNVGFFEVSLLENILSYILQTEVIPSANAKLSKGFPLPNLANITLTRPRIAIVQVRF
    

Molecular Weight51040.51 Da

Isoelectric Point (pI)8.37

Net Charge (pH 7.0)2.91

Net Charge (pH 7.4) 2.25

Charge Density (pH 7.0) 0.0063

GRAVY Index0.13

Hydrophobic Moment 0.77

Boman Index0.14

Instability Index37.42

Aliphatic Index 100.07

Aromaticity 0.1024

Extinction Coeff. Reduced 37820.00

Extinction Coeff. Oxidized 38195.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0320221 VERIFIED: NO

Provenance & Taxonomy

OrganismAnas platyrhynchos platyrhynchos [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence