Peptide Database

Peptide NameBeta-defensin 12

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length78 amino acids

Chemical FormulaC390H604N106O106S8

DescriptionStandard

        MALSRGTFYFGLALFFIVVELPSGSWAGLEYSQSFPGGEFAVCETCRLGRGKCRRTCLDSEKIAGKCKLNFFCCRERI
    

Molecular Weight8730.13 Da

Isoelectric Point (pI)8.79

Net Charge (pH 7.0)3.44

Net Charge (pH 7.4) 3.11

Charge Density (pH 7.0) 0.0441

GRAVY Index0.15

Hydrophobic Moment 0.56

Boman Index0.07

Instability Index38.00

Aliphatic Index 72.56

Aromaticity 0.1410

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8855.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3409.42

LogP -30.92

H-bond Donors 130.0

H-bond Acceptors 118.0

Rotatable Bonds 288.0

Heavy Atoms 610.0

Ring Count 14.0

Amide Bonds 79.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0068067 VERIFIED: NO

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyDefensin

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin Non-hemolytic Non-ribosomal

MethodQualitative functional evidence

PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/; https://www.uniprot.org/uniprotkb/Q32ZH9/entry; https://bblserver.org.in/ampdb/