Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length457 amino acids

Chemical FormulaC2233H3526N602O655S15

DescriptionStandard

        MLQSMLQKEHELNLTGSYNTPLLGTLTYTVPRIHIHELQMNESTLDFAEDVGLRLTVQRARIQLSADWAAQLGAVQDSGSVELRMQDLAVAAVLGVSEDGSGHPTVWSAGCDTRGTDLHMEFQRGYSWLYNLLAPLLQRTLQQQLNKQGLQDPAVGLDPDRARLWEGAGGLTPPDHLHVPAVSTQLDTIAAIDYSLLGPPTFTEEYGDIALKGEIFRVGTYQQRRSALPAVPPVAPGMALPVALPTPLPTTPPLAHEPMLLLAVTELVASSAAFTYFTAGALRRNISSAMLPRRFPLQLRTKSMEVFSPQLQEHYPDHPMELQLWARQQPLLSCHADALHGTLFSSAEAFVVLPNATRVPAFLLNIDANVTGKPTITRNRLGGTVRLTGLVSDPELGLSSPRTYLESSPIPHLCPFASLSPVLLEYCLSDPILPPVHICATALAGFVLIATDLQYEP
    

Molecular Weight49766.50 Da

Isoelectric Point (pI)5.42

Net Charge (pH 7.0)-13.26

Net Charge (pH 7.4) -14.33

Charge Density (pH 7.0) -0.0290

GRAVY Index0.02

Hydrophobic Moment 0.59

Boman Index0.12

Instability Index55.39

Aliphatic Index 99.93

Aromaticity 0.0656

Extinction Coeff. Reduced 45380.00

Extinction Coeff. Oxidized 45630.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0345043 VERIFIED: NO

Provenance & Taxonomy

OrganismLonchura striata domestica [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence