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MYP_112590
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Basic Information
Uperolein
Antimicrobial
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide signaling
Neurological / Signaling ▸ Tachykinin peptide
Regulatory peptide ▸ Biological modulation
Standard
11 amino acids
C57H81N13O17S
Standard
Sequence
QPDPNAFYGLM
Physicochemical Analysis
1252.39 Da
4.05
-1.24
-1.44
-0.1127
-0.46
0.23
0.18
41.66
44.55
0.1818
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
480.45
-3.48
14.0
17.0
35.0
88.0
4.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0033549 VERIFIED: YES
Provenance & Taxonomy
Uperoleia rugosa [Animal]
Uperolein
8368
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
Amidation
Bio-Activity Profile
Neuropeptide Neuromodulator Vasoactive Vasodilator Receptor modulation
Mammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Uperolein (Uperoleia rugosa): PMID 1120493 PMID1120493 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1120493/
RECORD: Rec_0120147 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
PaperDADP: the database of anuran defense peptides PMID22467909 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467909/
RECORD: Rec_0187449 VERIFIED: YES
Provenance & Taxonomy
Uperoleia rugosa [Animal]
Uperolein
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Smooth muscle contraction
PaperM.A. Apponyi et al. / Peptides 25 (2004) 1035-1054. Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance PMID15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15203252/
RECORD: Rec_0202243 VERIFIED: YES
Provenance & Taxonomy
Uperoleia rugosa [Animal]
tachykinin family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Pyroglutamate
Amidation
Bio-Activity Profile
Neuropeptide tachykinin family Neuropeptide signaling Host defense
PaperPDB 2GFR structural record; NMR; chain A; residues 1-11
RECORD: Rec_0394743 VERIFIED: YES
Provenance & Taxonomy
Uperoleia rugosa [Animal]
Tachykinin
8368
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Pyroglutamate
Leu10 Amidation
Bio-Activity Profile
Tachykinin Neuropeptide Neuromodulator
PMID1120493 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1120493/