Peptide Database

Peptide NameSLAY-screened peptide P1254

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC108H174N28O29S2

DescriptionStandard

        HTRLPTDGFCTLFKVTLLICN
    

Molecular Weight2392.84 Da

Isoelectric Point (pI)8.07

Net Charge (pH 7.0)0.83

Net Charge (pH 7.4) 0.54

Charge Density (pH 7.0) 0.0394

GRAVY Index0.53

Hydrophobic Moment 0.48

Boman Index0.19

Instability Index15.39

Aliphatic Index 106.67

Aromaticity 0.0952

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 914.44

LogP -7.31

H-bond Donors 34.0

H-bond Acceptors 33.0

Rotatable Bonds 75.0

Heavy Atoms 167.0

Ring Count 4.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0327373 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/