Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length360 amino acids

Chemical FormulaC1790H2776N456O513S22

DescriptionStandard

        MLYIVLWSLALVSCICGENPAIQLALTDKGLQTGKVNPTVILCVCFSMHITKLDFPEPEVHFSPPVSGLDLSVSGLSMALTGDWSTHLGTSFLVLVCSHDGGTFDMAIFDLSLRSFLGLDRDSSGHPSVSSVYCEVDIQTVNMQFYGGARYTHVCPCVENAIQSLERHLQAINMSVEVNPVMSLDLSLSAPPAVDPGSINFGLRGEFYSPESHRDPPFVAPPFSLPVQSTYMLSVGVSEYTANSASFAYYISGHLQALINDSMIPSYCPIRLNTSSMGRFIPQLSQMYPDLLMVLQVYARQTPLFTFQPGFVKLDLLSAIKAFVVQANSTLTPVFKLHLVRRTSRSGLVWFSMQRFNILK
    

Molecular Weight39597.37 Da

Isoelectric Point (pI)5.89

Net Charge (pH 7.0)-5.69

Net Charge (pH 7.4) -6.60

Charge Density (pH 7.0) -0.0158

GRAVY Index0.28

Hydrophobic Moment 0.71

Boman Index0.20

Instability Index49.49

Aliphatic Index 97.14

Aromaticity 0.1000

Extinction Coeff. Reduced 34380.00

Extinction Coeff. Oxidized 34880.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0184987 VERIFIED: NO

Provenance & Taxonomy

OrganismPeriophthalmus magnuspinnatus [Bacterium]

FamilyBPI

Tax ID409849

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence