‹ ›
MYP_112488
← PREVIOUS NEXT → BACK
Basic Information
O-17 (Oncocin)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxicity
not Standard
19 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
VDKPPYLPRPRPPRXIYNX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0171624 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Oncocin
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
Orn=Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial
Micrococcus luteus ATCC 10240
8 μg/mL
MIC
Mouse serum: The half-life is 176 ±8 min in full mouse serum
PaperKnappe D, Kabankov N, Hoffmann R Bactericidal oncocin derivatives with superior serum stabilities Int J Antimicrob Agents. 2011 Feb;37(2):166-70. PMID:21185160 https://pubmed.ncbi.nlm.nih.gov/21185160/ PMID21185160 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21185160/
RECORD: Rec_0221308 VERIFIED: YES
Provenance & Taxonomy
Oncopeltus fasciatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
L-Ornithine at 15,19; L-Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli BW25113
32 μg/mL
MIC
PMID29309652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29309652/
RECORD: Rec_0223917 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
ornithine at 15,19; C-terminal amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Proteus vulgaris ICB9081
8 μg/mL
MIC
PaperOncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against Gram-negative human pathogens PMID20565063 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20565063/
RECORD: Rec_0226329 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
ornithine at 15,19; C-terminal amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Pseudomonas aeruginosa PAO1
2 μg/mL
MIC
PaperOncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against Gram-negative human pathogens PMID20565063 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20565063/
RECORD: Rec_0240923 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
ornithine at 15,19; C-terminal amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Enterobacter cloacae Ha088
0.25 μg/mL
MIC
PaperOncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against Gram-negative human pathogens PMID20565063 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20565063/
FIRST PREV 1 ... 4 5 6 7 8 ... 13 NEXT LAST
Showing 5 records · Page 6 of 13