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MYP_112488
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Basic Information
O-17 (Oncocin)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxicity
not Standard
19 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
VDKPPYLPRPRPPRXIYNX
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0076324 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
ornithine at 15,19
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
K. pneumoniaeATCC 43816
16 μg/mL
MIC
PMID25968331 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25968331/
RECORD: Rec_0087589 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
ornithine at 15,19; C-terminal amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Enterobacter cloacae 34654
0.5 μg/mL
MIC
PaperOncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against Gram-negative human pathogens PMID20565063 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20565063/
RECORD: Rec_0101355 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
ornithine at 15,19; C-terminal amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Klebsiella pneumoniae 63
2 μg/mL
MIC
PaperOncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against Gram-negative human pathogens PMID20565063 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20565063/
RECORD: Rec_0103773 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
ornithine at 15,19; C-terminal amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Proteus vulgaris ICB9095
4 μg/mL
MIC
PaperOncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against Gram-negative human pathogens PMID20565063 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20565063/
RECORD: Rec_0105910 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Oncocin
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
Har=Homoarginine, Agp = α-amino-3-guanidinopropionic acid
Bio-Activity Profile
Antimicrobial Antibacterial
Micrococcus luteus ATCC 10240
2 μg/mL
MIC
Mouse serum: The half-life is 111 ±6 min in full mouse serum
PaperKnappe D, Kabankov N, Hoffmann R Bactericidal oncocin derivatives with superior serum stabilities Int J Antimicrob Agents. 2011 Feb;37(2):166-70. PMID:21185160 https://pubmed.ncbi.nlm.nih.gov/21185160/ PMID21185160 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21185160/
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