‹ ›
MYP_112488
← PREVIOUS NEXT → BACK
Basic Information
O-17 (Oncocin)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxicity
not Standard
19 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
VDKPPYLPRPRPPRXIYNX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0013994 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Oncocin
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
Har=Homoarginine
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli DSM 1103
8 μg/mL
MIC
Mouse serum: The half-life is 55 ±0 min in full mouse serum
PaperKnappe D, Kabankov N, Hoffmann R Bactericidal oncocin derivatives with superior serum stabilities Int J Antimicrob Agents. 2011 Feb;37(2):166-70. PMID:21185160 https://pubmed.ncbi.nlm.nih.gov/21185160/ PMID21185160 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21185160/
RECORD: Rec_0024805 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
ornithine at 15,19
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Pseudomonas aeruginosa ATCC 27853
2 μg/mL
PMID20565063 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20565063/
RECORD: Rec_0028439 VERIFIED: YES
Provenance & Taxonomy
Oncopeltus fasciatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
L-Ornithine at 15,19; L-Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Klebsiella pneumoniae ATCC 10031
2 μg/mL
MIC
PMID29309652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29309652/
RECORD: Rec_0028845 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Oncocin
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
Agp = α-amino-3-guanidinopropionic acid, Orn=Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial
Micrococcus luteus ATCC 10240
4 μg/mL
MIC
Mouse serum: The half-life is 103 ±5 min in full mouse serum
PaperKnappe D, Kabankov N, Hoffmann R Bactericidal oncocin derivatives with superior serum stabilities Int J Antimicrob Agents. 2011 Feb;37(2):166-70. PMID:21185160 https://pubmed.ncbi.nlm.nih.gov/21185160/ PMID21185160 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21185160/
RECORD: Rec_0037178 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Oncocin
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
Har=Homoarginine, Agp = α-amino-3-guanidinopropionic acid
Bio-Activity Profile
Antimicrobial Antibacterial
Micrococcus luteus ATCC 10240
4 μg/mL
MIC
Mouse serum: The half-life is 62 ±4 min in full mouse serum
PaperKnappe D, Kabankov N, Hoffmann R Bactericidal oncocin derivatives with superior serum stabilities Int J Antimicrob Agents. 2011 Feb;37(2):166-70. PMID:21185160 https://pubmed.ncbi.nlm.nih.gov/21185160/ PMID21185160 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21185160/
1 2 3 ... 15 NEXT LAST
Showing 5 records on this page · Page 1 of 15