Peptide Database

Peptide NameE1P43

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC119H160N26O29

DescriptionStandard

        FWRWTEQLASNYWILEYL
    

Molecular Weight2418.70 Da

Isoelectric Point (pI)4.53

Net Charge (pH 7.0)-1.24

Net Charge (pH 7.4) -1.45

Charge Density (pH 7.0) -0.0687

GRAVY Index-0.27

Hydrophobic Moment 0.58

Boman Index0.19

Instability Index59.26

Aliphatic Index 92.22

Aromaticity 0.3333

Extinction Coeff. Reduced 19480.00

Extinction Coeff. Oxidized 19480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 908.99

LogP -1.34

H-bond Donors 33.0

H-bond Acceptors 28.0

Rotatable Bonds 72.0

Heavy Atoms 174.0

Ring Count 9.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0058547 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAurein

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetHIV-1 NL4-3

Activity43±10.8 μM

MethodIC50

RECORD: Rec_0308531 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetVirus:HIV-1 NL4-3:inhibition of virus infection in TZM-bl cells

Activity43±10.8 μM

MethodIC50

RECORD: Rec_0339695 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1 NL4-3 | TZM-bl cells

Activity43±10.8 μM

MethodIC50

Half-LifeMammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min

PaperDefinition of an 18-mer Synthetic Peptide Derived from the GB virus C E1 Protein as a New HIV-1 Entry Inhibitor. | Gómara MJ, Sánchez-Merino V, Paús A, Merino-Mansilla A, Gatell JM, Yuste E, Haro I. | Biochim Biophys Acta. 2016 Jun;1860(6):1139-48. | DOI:10.1016/j.bbagen.2016.02.008 | PMID:26905802 PMID26905802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26905802/