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MYP_112439
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Basic Information
30(derived from HCV C5A)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition
Antiviral ▸ Virucidal activity
Standard
18 amino acids
C117H157N25O27
Standard
Sequence
SWLWEVWDWVLHVLSDFK
Physicochemical Analysis
2345.65 Da
4.53
-2.45
-2.71
-0.1360
0.22
0.50
0.34
12.20
113.33
0.2778
22000.00
22000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
828.24
0.78
30.0
26.0
69.0
169.0
10.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0167487 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Hepatitis C virus (HCV, JFH-1); Huh-7/Huh-7.5.1 cells
7 μM
HCV infection inhibition assay (IC50; RT-PCR/immunodetection readout)
PaperA virocidal amphipathic alpha-helical peptide that inhibits hepatitis C virus infection in vitro. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3088-3093. doi: 10.1073/pnas.0712380105. PMID: 18287023. PMID18287023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18287023/
RECORD: Rec_0181771 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HCV Release inhibition
Hepatitis C virus (HCV); Huh-7.5.1 cells
7 μM
IC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperA virocidal amphipathic {alpha}-helical peptide that inhibits hepatitis C virus infection in vitro. | Cheng G, Montero A, Gastaminza P, Whitten-Bauer C, Wieland SF, Isogawa M, Fredericksen B, Selvarajah S, Gallay PA, Ghadiri MR, Chisari FV. | Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3088-93. | DOI:10.1073/pnas.0712380105 | PMID:18287023 PMID18287023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18287023/
RECORD: Rec_0203541 VERIFIED: YES
Provenance & Taxonomy
Hepatitis C virus [Virus]; synthetic construct [Synthetic]
Virus-derived peptide
3052230;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Virucidal
Hepatitis C virus (Viral membrane); Huh7
7 μM
HCV infection inhibition assay (IC50; RT-PCR/immunodetection readout)
PaperA virocidal amphipathic {alpha}-helical peptide that inhibits hepatitis C virus infection in vitro. | Cheng G, Montero A, Gastaminza P, Whitten-Bauer C, Wieland SF, Isogawa M, Fredericksen B, Selvarajah S, Gallay PA, Ghadiri MR, Chisari FV. | Proc Natl Acad Sci U S A. 2008 | PMID:18287023 PMID18287023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18287023/
RECORD: Rec_0282538 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Hepatitis C virus HCV JFH-1
7 μM
HCV infection inhibition assay (IC50; RT-PCR/immunodetection readout)
PaperA virocidal amphipathic alpha-helical peptide that inhibits hepatitis C virus infection in vitro PMID18287023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18287023/
RECORD: Rec_0305045 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Hepatitis C virus (HCV, JFH-1); Huh-7/Huh-7.5.1 cells
7 μM
IC50
PaperA virocidal amphipathic alpha-helical peptide that inhibits hepatitis C virus infection in vitro. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3088-3093. doi: 10.1073/pnas.0712380105. PMID: 18287023. PMID18287023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18287023/
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