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MYP_112428
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Basic Information
Bombinin-like peptide 2 (BLP-2; toads, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
27 amino acids
C115H193N33O34
Standard
Sequence
GIGSAILSAGKSALKGLAKGLAEHFAN
Physicochemical Analysis
2581.96 Da
9.70
1.85
1.59
0.0684
0.43
0.60
0.27
-5.59
108.89
0.0370
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1067.74
-12.13
37.0
37.0
89.0
182.0
2.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0141641 VERIFIED: YES
Provenance & Taxonomy
Oriental fire-bellied toad [Animal]
Bombinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
N. meningitidis strains 118V, 15240, 126E, N. gonorrhoeae, N. lactamica
PaperBombinin-like peptides with antimicrobial activity from skin secretions of the Asian toad, Bombina orientalis.
RECORD: Rec_0153329 VERIFIED: YES
Provenance & Taxonomy
Bombina orientalis [Animal]
Bombinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-negative
58 % inhibition Neisseria meningitidis 118V C
20 μg/mL
MIC
PMID1744108 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1744108/
RECORD: Rec_0155469 VERIFIED: YES
Provenance & Taxonomy
Bombina orientalis [Animal]
Bombinin
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Antifungal
PMID1744108 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1744108/
RECORD: Rec_0171013 VERIFIED: YES
Provenance & Taxonomy
Bombina orientalis [Animal]
Bombinin
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Antifungal
98% inhibition Neisseria meningitidis 126E IC1
20 μg/mL
MIC
PMID1744108 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1744108/
RECORD: Rec_0185838 VERIFIED: YES
Provenance & Taxonomy
Bombina orientalis [Animal]
Bombinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-negative
95% inhibition Neisseria cinerea 15461
20 μg/mL
MIC
PMID1744108 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1744108/
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