Peptide Database

Peptide NameUnnamed

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ Tripeptidyl Peptidase II Inhibitory

Standard StatusStandard

Sequence Length3 amino acids

Chemical FormulaC18H25N3O7S

DescriptionStandard

DYM

Molecular Weight427.47 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-1.24

Net Charge (pH 7.4) -1.44

Charge Density (pH 7.0) -0.4133

GRAVY Index-0.97

Hydrophobic Moment 0.52

Boman Index0.00

Instability Index153.13

Aliphatic Index 0.00

Aromaticity 0.3333

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 179.05

LogP -0.46

H-bond Donors 6.0

H-bond Acceptors 7.0

Rotatable Bonds 12.0

Heavy Atoms 29.0

Ring Count 1.0

Amide Bonds 2.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0140388 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630.0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Tripeptidyl Peptidase II Inhibitory

TargetTripeptidyl peptidase II / CCK-8-inactivating peptidase

PaperGanellin C. R., Bishop P. B., Bambal R. B., Chan S. M., Law J. K., Marabout B., Luthra P. M., Moore A. N., Peschard O., Bourgeat P., Rose C., Vargas F.. Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J. Med. Chem., 43, 664-674, 2000. PMID10691692 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10691692/