Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length507 amino acids

Chemical FormulaC2439H3873N619O739S18

DescriptionStandard

        MVLQIWLLLVALTSSTFGINPGVKVTLTQKGLEYGREIGIAAIQRKLNTINLPDISGSERVFLIGKVKYSFTNMHLTNVGLPQSAVSPVPGAGVQLSIGNAYMSLNGNWRVKYLRVIKDSGSFDLNVNGLSITTTIAISSDETGRPTVSGTNCAASVGSVSIKFHGGASWLYNLFSSFIEKALRSALQEKICPLITDAISDVNPSLKTLNVLAKVDEFAEIEYSMTSSPVISASSVDLSLKGEFYNIGMHQEPPFTPAVFSMPSQSNNMLNIGLSSFTANSAGFVYYTAGALSLYITDDMISASSPIRLNTQTFGAFIPQIAQSFPGLMVKLLVKAVKPPVITFESDNAMIQATGTVTAYAIQTDGTLSPLFVLNMDGSVSAQVSVSGTMVAGSVTLNKMDLTLGTSYFGDFQVKSIDRIFQAVLKVVIIPMLNAQLAKGYPLPTIGKMTLVNTQLQIMKDYVLIGTDVQFAADDSSGTNHIDDYVLIGTDVPFAGDYSSRTNHIDV
    

Molecular Weight54268.71 Da

Isoelectric Point (pI)5.60

Net Charge (pH 7.0)-5.06

Net Charge (pH 7.4) -5.65

Charge Density (pH 7.0) -0.0100

GRAVY Index0.26

Hydrophobic Moment 0.81

Boman Index0.20

Instability Index36.23

Aliphatic Index 100.93

Aromaticity 0.0828

Extinction Coeff. Reduced 40340.00

Extinction Coeff. Oxidized 40465.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0169310 VERIFIED: NO

Provenance & Taxonomy

OrganismNeogobius melanostomus [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence