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MYP_112283
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Basic Information
Neuropeptide-like peptide nlp-32-9
Anticancer
Antimicrobial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Standard
3 amino acids
C6H11N3O4
Standard
Sequence
GGG
Physicochemical Analysis
189.17 Da
5.53
-0.24
-0.44
-0.0800
-0.40
0.10
0.48
88.93
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
121.52
-2.74
4.0
4.0
5.0
13.0
0.0
2.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0188625 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Source entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata
Conjugate type: amide; Conjugated small molecule: Camptothecin
Bio-Activity Profile
Anticancer
PaperDeterminants for the drug release from T-0128, camptothecin analog-carboxymethyl dextran conjugate. Journal of Controlled Release. 2000 Evidence URLhttps://doi.org/10.1016/s0168-3659(00
RECORD: Rec_0193657 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
4.44 pIC50
pIC50
PaperWhat are the ideal properties for functional food peptides with antihypertensive effect? A computational peptidology approach. PMID23871047 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23871047/
RECORD: Rec_0204393 VERIFIED: NO
Provenance & Taxonomy
Caenorhabditis elegans [Animal]
GGG-amide
6239
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
2:Glycine amide
Bio-Activity Profile
Antimicrobial Neuropeptide Neuromodulator
Mammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for GGG-amide (Caenorhabditis elegans): PMID 11717458 PMID11717458 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11717458/
RECORD: Rec_0377769 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Evidence URLhttps://patents.google.com/patent/US20080170991A1/en PatentUS 2008/0170991 A1
RECORD: Rec_0402062 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Tri-Gly
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium berghei
100 μM
Percent inhibition; Microscopy (Number of ookinetes counted)
PMID9799128 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9799128/
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