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MYP_112278
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Basic Information
Beta-defensin 130
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Standard
57 amino acids
C277H454N78O77S6
Standard
Sequence
GVIPGQKQCIALKGVCRDKLCSTLDDTIGICNEGKKCCRRWWILEPYPTPVPKGKSP
Physicochemical Analysis
6301.43 Da
9.06
4.70
4.39
0.0825
-0.36
0.71
-0.05
41.08
78.60
0.0526
12490.00
12865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2476.75
-22.87
90.0
88.0
205.0
438.0
11.0
59.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0267719 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiparasitic Anti-inflammatory
Bacillus subtilis ATCC 6633
40 μg/mL
MIC
PaperInvolvement of beta-defensin 130 (DEFB130) in the macrophage microbicidal mechanisms for killing Plasmodium falciparum.
RECORD: Rec_0289519 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Evidence URLhttps://www.uniprot.org/uniprotkb/Q30KQ2/entry
RECORD: Rec_0293368 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiparasitic Anti-inflammatory
P. falciparum
43-49 μM
IC50
PaperInvolvement of beta-defensin 130 (DEFB130) in the macrophage microbicidal mechanisms for killing Plasmodium falciparum.
RECORD: Rec_0319341 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiparasitic Anti-inflammatory
Staphylococcus aureus ATCC 25923
45 μg/mL
MIC
PaperInvolvement of beta-defensin 130 (DEFB130) in the macrophage microbicidal mechanisms for killing Plasmodium falciparum.
RECORD: Rec_0386503 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiparasitic Anti-inflammatory
E. sakazakii ATCC 29544
15 μg/mL
MIC
PaperInvolvement of beta-defensin 130 (DEFB130) in the macrophage microbicidal mechanisms for killing Plasmodium falciparum.
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