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MYP_112226
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Basic Information
p776
Anticancer
Anticancer ▸ Antitumor
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
15 amino acids
C69H116N18O19S
Standard
Sequence
GVGSPYVSRLLGICL
Physicochemical Analysis
1533.83 Da
8.22
0.75
0.53
0.0499
1.11
0.37
0.40
52.99
142.67
0.0667
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
584.52
-4.79
22.0
21.0
47.0
107.0
2.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0035237 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens ERBB2/HER2 [Animal]; synthetic construct [Synthetic]
Designed peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Immunomodulatory HER2/neu CD4 T-cell epitope Antitumor vaccine antigen
HER2/neu p776-specific CD4+ T cells; TUBO.A2 breast tumor model
IFN-γ ELISPOT and tumor-growth assay
PaperA novel CD4 T-cell epitope in the HER2/neu protein eliciting antitumor immune responses PMID21928125 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21928125/
RECORD: Rec_0092445 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens ERBB2/HER2 [Animal]; synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Immunomodulatory HER2/neu CD4 T-cell epitope Antitumor vaccine antigen
HER2/neu p776-specific CD4+ T cells; TUBO.A2 breast tumor model
IFN-γ ELISPOT and tumor-growth assay
PaperA novel CD4 T-cell epitope in the HER2/neu protein eliciting antitumor immune responses PMID21928125 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21928125/
RECORD: Rec_0144747 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0269643 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens ERBB2/HER2 [Animal]; synthetic construct [Synthetic]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Immunomodulatory HER2/neu CD4 T-cell epitope Antitumor vaccine antigen
HER2/neu p776-specific CD4+ T cells; TUBO.A2 breast tumor model
IFN-γ ELISPOT and tumor-growth assay
PaperA novel CD4 T-cell epitope in the HER2/neu protein eliciting antitumor immune responses PMID21928125;25270878 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25270878/