Peptide Database

Peptide Name[Ala21]PACAP38

Function Ontology

Neuroprotective

Standard StatusStandard

Sequence Length38 amino acids

Chemical FormulaC200H323N61O54S

DescriptionStandard

        HSDGIFTDSYSRYRKQMAVKAYLAAVLGKRYKQRVKNK
    

Molecular Weight4478.15 Da

Isoelectric Point (pI)10.35

Net Charge (pH 7.0)7.84

Net Charge (pH 7.4) 7.57

Charge Density (pH 7.0) 0.2063

GRAVY Index-0.91

Hydrophobic Moment 0.56

Boman Index-0.30

Instability Index35.97

Aliphatic Index 64.21

Aromaticity 0.1316

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 5960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1938.13

LogP -18.92

H-bond Donors 71.0

H-bond Acceptors 64.0

Rotatable Bonds 155.0

Heavy Atoms 316.0

Ring Count 6.0

Amide Bonds 40.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0338999 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyPACAP

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Neuroprotective

Activity0.002±0.0005 μM

MethodIC50

Half-LifeHuman plasma, in vitro; 396 s