Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length121 amino acids

Chemical FormulaC597H975N163O161S7

DescriptionStandard

        TKCATGRMFLCCWLVLGALFPATLSINPGVKVRLTEKGIEYGKVCVKAQKLNSIQVPDFSGEQRVSPIGKVQYNLSNIHVLKVGIPKSSVDLVPGTGVRMSIGDAFISLNGNWRVKYLRIM
    

Molecular Weight13236.58 Da

Isoelectric Point (pI)9.86

Net Charge (pH 7.0)9.44

Net Charge (pH 7.4) 9.12

Charge Density (pH 7.0) 0.0781

GRAVY Index0.20

Hydrophobic Moment 0.63

Boman Index0.12

Instability Index20.27

Aliphatic Index 105.37

Aromaticity 0.0744

Extinction Coeff. Reduced 15470.00

Extinction Coeff. Oxidized 15720.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5193.05

LogP -46.31

H-bond Donors 184.0

H-bond Acceptors 179.0

Rotatable Bonds 441.0

Heavy Atoms 928.0

Ring Count 18.0

Amide Bonds 130.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0390767 VERIFIED: NO

Provenance & Taxonomy

OrganismMaylandia zebra [Bacterium]

FamilyBPI

Tax ID106582

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence