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MYP_112068
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Basic Information
Temporin-SHd
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
17 amino acids
C82H132N18O18
Standard
Sequence
FLPAALAGIGGILGKLF
Physicochemical Analysis
1658.03 Da
8.75
0.76
0.55
0.0447
1.65
0.36
0.69
30.68
155.29
0.1176
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
546.15
-0.86
18.0
19.0
52.0
118.0
3.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0112098 VERIFIED: YES
Provenance & Taxonomy
Pelophylax saharicus [Animal]
Temporin
70019
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiparasitic Anti-Trypanosoma cruzi
Trypanosoma cruzi Y cl7 scl2, DTU2b (epimastigote)
~17 μM
IC50; FACScan flow cytometer staining with propidium iodide
PaperAntibacterial and leishmanicidal activities of temporin-SHd, a 17-residue long membrane-damaging peptide PMID23116712 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23116712/
RECORD: Rec_0118941 VERIFIED: YES
Provenance & Taxonomy
Pelophylax saharica [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiparasitic Toxicity
Human THP-1 monocytes
66 μM
LC50
PaperTemporin-SHf, a new type of phe-rich and hydrophobic ultrashort antimicrobial peptide
RECORD: Rec_0123714 VERIFIED: YES
Provenance & Taxonomy
Pelophylax saharicus [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Candida parapsilosis ATCC 22019
200 μM
MIC
PMID23116712 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23116712/
RECORD: Rec_0125123 VERIFIED: YES
Provenance & Taxonomy
Pelophylax saharicus [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Klebsiella pneumoniae ATCC 13883
100 μM
MIC
PMID23116712 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23116712/
RECORD: Rec_0126053 VERIFIED: YES
Provenance & Taxonomy
Pelophylax saharicus [Animal]
Temporin
70019
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiparasitic Antileishmanial
Leishmania infantum MHOM/MA/67/ITMAP-263 (amastigote axenic)
6.7 μM
IC50; Luminescence-Steady-Glo Assay system
PaperAntibacterial and leishmanicidal activities of temporin-SHd, a 17-residue long membrane-damaging peptide PMID23116712 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23116712/
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