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MYP_112068
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Basic Information
Temporin-SHd
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
17 amino acids
C82H132N18O18
Standard
Sequence
FLPAALAGIGGILGKLF
Physicochemical Analysis
1658.03 Da
8.75
0.76
0.55
0.0447
1.65
0.36
0.69
30.68
155.29
0.1176
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
546.15
-0.86
18.0
19.0
52.0
118.0
3.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0311828 VERIFIED: YES
Provenance & Taxonomy
Pelophylax saharicus [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Bacillus megaterium
1.56 μM
MIC
PMID23116712 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23116712/
RECORD: Rec_0318651 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0338673 VERIFIED: YES
Provenance & Taxonomy
Pelophylax saharicus [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Staphylococcus aureus ATCC BAA-44
6.25 μM
MIC
PMID23116712 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23116712/
RECORD: Rec_0345993 VERIFIED: YES
Provenance & Taxonomy
Pelophylax saharicus [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal Antifungal
Human acute monocytic leukemia THP-1
66 μM
LC50
PMID23116712 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23116712/
RECORD: Rec_0348143 VERIFIED: YES
Provenance & Taxonomy
Pelophylax saharicus [Animal]
Temporin
70019
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiparasitic Antileishmanial
Leishmania amazonensis MHOM/BR/73/M2269
~14 μM
IC50; FACScan flow cytometer staining with propidium iodide
PaperAntibacterial and leishmanicidal activities of temporin-SHd, a 17-residue long membrane-damaging peptide PMID23116712 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23116712/
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