Peptide Database

Peptide NameSLAY-screened peptide P81

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC54H84N16O21

DescriptionStandard

        TASHSSSQYPKT
    

Molecular Weight1293.34 Da

Isoelectric Point (pI)8.29

Net Charge (pH 7.0)0.48

Net Charge (pH 7.4) 0.24

Charge Density (pH 7.0) 0.0403

GRAVY Index-1.36

Hydrophobic Moment 0.29

Boman Index-0.21

Instability Index61.32

Aliphatic Index 8.33

Aromaticity 0.0833

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 614.03

LogP -10.70

H-bond Donors 22.0

H-bond Acceptors 23.0

Rotatable Bonds 39.0

Heavy Atoms 91.0

Ring Count 3.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0410794 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/