Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length176 amino acids

Chemical FormulaC855H1365N237O237S7

DescriptionStandard

        PAALPMAHEPMLLLAVTEFVANSAAFTYFTAGALRRNISSNMLPRRFPLQLRTKNMGLFSPQLQERYPDQPMELHLSARRQPLLSCHPDALHGALFSSAEAFVVLPNATRVPAFLLNIDANVTGKPTITGNRLGGTVSLKGELSPFPTSGLLPLSPVSRAGTPSRPWLLAMPTALS
    

Molecular Weight18980.89 Da

Isoelectric Point (pI)10.46

Net Charge (pH 7.0)6.31

Net Charge (pH 7.4) 6.02

Charge Density (pH 7.0) 0.0359

GRAVY Index0.07

Hydrophobic Moment 0.57

Boman Index0.12

Instability Index63.01

Aliphatic Index 93.24

Aromaticity 0.0682

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7408.73

LogP -83.48

H-bond Donors 254.0

H-bond Acceptors 254.0

Rotatable Bonds 595.0

Heavy Atoms 1336.0

Ring Count 37.0

Amide Bonds 188.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0257187 VERIFIED: NO

Provenance & Taxonomy

OrganismCharadrius vociferus [Animal]

FamilyBPI/LBP

Tax ID50402

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria