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MYP_111928
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Basic Information
Brevinin-2E (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
33 amino acids
C142H252N42O45S3
Standard
Sequence
GIMDTLKNLAKTAGKGALQSLLNKASCKLSGQC
Physicochemical Analysis
3363.97 Da
9.60
3.74
3.50
0.1132
-0.03
0.66
0.03
27.67
94.85
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1435.43
-18.41
51.0
52.0
121.0
232.0
0.0
36.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0257484 VERIFIED: YES
Provenance & Taxonomy
Rana esculenta [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
PMID8508915 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8508915/
RECORD: Rec_0313112 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Toxic Antimicrobial Hemolytic
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0326600 VERIFIED: YES
Provenance & Taxonomy
Rana esculenta [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus Cowan 1
2 μM
MIC
PMID8508915 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8508915/
RECORD: Rec_0373796 VERIFIED: YES
Provenance & Taxonomy
Pelophylax esculentus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Evidence URLhttps://patents.google.com/patent/US20050260715A1/en PatentUS 2005/0260715 A1
RECORD: Rec_0384614 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
100 μM
LC50
Paperhttps://pubmed.ncbi.nlm.nih.gov/8508915/ PMID8508915 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8508915/
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