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MYP_111928
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Basic Information
Brevinin-2E (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
33 amino acids
C142H252N42O45S3
Standard
Sequence
GIMDTLKNLAKTAGKGALQSLLNKASCKLSGQC
Physicochemical Analysis
3363.97 Da
9.60
3.74
3.50
0.1132
-0.03
0.66
0.03
27.67
94.85
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1435.43
-18.41
51.0
52.0
121.0
232.0
0.0
36.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0173536 VERIFIED: YES
Provenance & Taxonomy
Pelophylax esculentus [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial
Escherichia coli D21 (LC 0.5 uM), Bacillus megaterium BmII (LC 0.2 uM), Staphylococcus aureus Cowan 1 (LC 2.0 uM), Candida albicans
PaperAntimicrobial Peptides From Skin Secretions of Rana Esculenta. Molecular Cloning of cDNAs Encoding Esculentin and Brevinins and Isolation of New Active Peptides
RECORD: Rec_0233323 VERIFIED: YES
Provenance & Taxonomy
Rana esculenta [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Pseudomonas aeruginosa ATCC 15692
30 μM
MIC
PMID8508915 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8508915/
RECORD: Rec_0243398 VERIFIED: YES
Provenance & Taxonomy
Rana esculenta [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli D21
0.5 μM
MIC
PMID8508915 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8508915/
RECORD: Rec_0245135 VERIFIED: NO
Provenance & Taxonomy
Rana esculenta [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperPatent US 7862826 B2 Evidence URLhttps://patents.google.com/patent/US7862826B2/en PatentUS 7862826 B2
RECORD: Rec_0253282 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperSimmaco M., Mignogna G., Barra D., Bossa F.. Novel antimicrobial peptides from skin secretion of the European frog Rana esculenta. FEBS Lett., 324, 159-161, 1993.
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