Peptide Database

Peptide NameDermaseptin-A4

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length72 amino acids

Chemical FormulaC348H569N91O113S5

DescriptionStandard

        MAFLKKSLFLVLFLGMVSLSICEEEKREEENEQEDDEQSEEKRGMFTNMLKGIGKLAGQAALGAVKTLAGEQ
    

Molecular Weight7996.11 Da

Isoelectric Point (pI)4.67

Net Charge (pH 7.0)-5.48

Net Charge (pH 7.4) -5.74

Charge Density (pH 7.0) -0.0761

GRAVY Index-0.31

Hydrophobic Moment 0.67

Boman Index-0.01

Instability Index52.45

Aliphatic Index 85.42

Aromaticity 0.0556

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3337.48

LogP -30.91

H-bond Donors 113.0

H-bond Acceptors 113.0

Rotatable Bonds 289.0

Heavy Atoms 557.0

Ring Count 4.0

Amide Bonds 77.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0265581 VERIFIED: NO

Provenance & Taxonomy

OrganismAgalychnis annae [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Amphibian defense peptide Antibiotic Antimicrobial Anti-Gram-negative Anti-Gram-positive Non-hemolytic Non-ribosomal

TargetGram-negative bacteria; Gram-positive bacteria

MethodQualitative functional evidence