Peptide Database

Peptide NameAngiotensin I converting enzyme inhibitior 6

Function Ontology

Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Other / Curated residual function label ▸ Generic enzyme inhibition annotation

Standard StatusStandard

Sequence Length5 amino acids

Chemical FormulaC31H48N6O6

DescriptionStandard

        PLFPK
    

Molecular Weight600.75 Da

Isoelectric Point (pI)9.18

Net Charge (pH 7.0)0.96

Net Charge (pH 7.4) 0.90

Charge Density (pH 7.0) 0.1915

GRAVY Index-0.10

Hydrophobic Moment 0.46

Boman Index0.20

Instability Index46.52

Aliphatic Index 78.00

Aromaticity 0.2000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 182.96

LogP 0.69

H-bond Donors 6.0

H-bond Acceptors 7.0

Rotatable Bonds 16.0

Heavy Atoms 43.0

Ring Count 3.0

Amide Bonds 4.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0088009 VERIFIED: YES

Provenance & Taxonomy

OrganismMactra veneriformis [Animal]

FamilyAngiotensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Enzyme inhibitory ACE inhibitory

TargetAngiotensin-converting enzyme

Activity41.3 μM

MethodIC50

RECORD: Rec_0275390 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antihypertensive ACE inhibitory

TargetAngiotensin-converting enzyme (ACE)

Activity41.3

PaperLiu R., Zhu Y., Chen J., Wu H., Shi L., Wang X., Wang L.. Characterization of ACE inhibitory peptides from Mactra veneriformis hydrolysate by nano-liquid chromatography electrospray ionization mass spectrometry (Nano-LC-ESI-MS) and molecular docking. Mar. Drugs, 12, 3917-3928, 2014. Evidence URLhttps://pmc.ncbi.nlm.nih.gov/articles/PMC4113806/