‹ ›
MYP_111710
← PREVIOUS NEXT → BACK
Basic Information
Tachyplesin-1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Virucidal activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
17 amino acids
C99H154N34O20S4
Standard
Sequence
KWCFRVCYRGICYRRCR
Physicochemical Analysis
2268.76 Da
9.93
5.72
5.45
0.3363
-0.52
0.65
-0.44
13.22
40.00
0.2353
8480.00
8730.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
920.69
-6.48
41.0
30.0
72.0
157.0
5.0
16.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0410438 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
Structure & Mods
linear peptide with two intramolecular disulfide bonds [Linear]
canonical L-amino-acid peptide [L]
Amidation
3-16; 7-12
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25922
4-8 μM
MIC
PMID31455019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31455019/
RECORD: Rec_0411450 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
Tachyplesin
Structure & Mods
linear peptide with two intramolecular disulfide bonds [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
3-16; 7-12
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiviral Anti-HIV Anticancer
-
PMID12369825;2229025;31455019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12369825/
RECORD: Rec_0421720 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
Tachyplesin
Structure & Mods
linear peptide with two intramolecular disulfide bonds [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
3-16; 7-12
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiviral Anti-HIV Anticancer Cytotoxic
HL-60 acute promyelocytic leukemia cells; K562 myelogenous leukemia cells; TSU prostate cancer cells
Qualitative cytotoxicity assay
PMID12369825;2229025;31455019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12369825/
RECORD: Rec_0423513 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
Structure & Mods
linear peptide with two intramolecular disulfide bonds [Linear]
canonical L-amino-acid peptide [L]
Amidation
3-16; 7-12
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Klebsiella pneumoniae
PMID27331141 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27331141/
RECORD: Rec_0425143 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
Tachyplesin
Structure & Mods
linear peptide with two intramolecular disulfide bonds [Linear]
canonical L-amino-acid peptide [L]
Amidation
3-16; 7-12
Bio-Activity Profile
Antimicrobial Antiviral Anticancer
Candida albicans M9
3.1 μg/mL
MIC
PaperTachyplesin, a class of antimicrobial peptide from the hemocytes of the horseshoe crab (Tachypleus tridentatus). Isolation and chemical structure
FIRST PREV 1 ... 9 10 11
Showing 5 records · Page 11 of 11